Assay Detail
Functional
CHEMBL4009873
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Cytotoxicity against human KB cells assessed as reduction in cell viability after 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The derivatives of Pulsatilla saponin A, a bioactive compound from Pulsatilla chinensis: Their synthesis, cytotoxicity, haemolytic toxicity and mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.96 | 5.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100833 | — | — | 1 | 5.29 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.18 |
| CHEMBL486400 | HEDERAGENIN | — | 1 | 4.83 |
| CHEMBL4065449 | — | — | 1 | 4.83 |
| CHEMBL4067199 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100833 | — | IC50 | = | 5075.0 | nM | 5.29 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6587.0 | nM | 5.18 |
| CHEMBL486400 | HEDERAGENIN | IC50 | = | 14631.0 | nM | 4.83 |
| CHEMBL4065449 | — | IC50 | = | 14956.0 | nM | 4.83 |
| CHEMBL4067199 | — | IC50 | = | 20697.0 | nM | 4.68 |