Assay Detail
Functional
CHEMBL4009875
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The derivatives of Pulsatilla saponin A, a bioactive compound from Pulsatilla chinensis: Their synthesis, cytotoxicity, haemolytic toxicity and mechanism of action.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.74 | 4.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100833 | — | — | 1 | 4.97 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.94 |
| CHEMBL4067199 | — | — | 1 | 4.65 |
| CHEMBL486400 | HEDERAGENIN | — | 1 | 4.41 |
| CHEMBL4065449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100833 | — | IC50 | = | 10737.0 | nM | 4.97 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL4067199 | — | IC50 | = | 22219.0 | nM | 4.65 |
| CHEMBL486400 | HEDERAGENIN | IC50 | = | 39389.0 | nM | 4.41 |
| CHEMBL4065449 | — | IC50 | > | 40000.0 | nM | - |