Assay Detail
Functional
CHEMBL4009953
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat N-terminal FLAG-tagged TAAR1 expressed in HEK293 cells assessed as [3H]cAMP accumulation measured after 1 hr
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Trace amine-associated receptor 1 (CHEMBL3833) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.69 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1546 | HYDROXYAMPHETAMINE | 4.0 | 1 | 7.29 |
| CHEMBL11608 | TYRAMINE | 3.0 | 1 | 7.16 |
| CHEMBL610 | PHENETHYLAMINE | — | 1 | 6.62 |
| CHEMBL6640 | TRYPTAMINE | — | 1 | 6.51 |
| CHEMBL53929 | OCTOPAMINE | 2.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1546 | HYDROXYAMPHETAMINE | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL11608 | TYRAMINE | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL610 | PHENETHYLAMINE | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL6640 | TRYPTAMINE | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL53929 | OCTOPAMINE | EC50 | = | 1300.0 | nM | 5.89 |