Assay Detail
Binding
CHEMBL4009981
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Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The 2014 Philip S. Portoghese Medicinal Chemistry Lectureship: The "Phenylalkylaminome" with a Focus on Selected Drugs of Abuse.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.87 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165520 | — | — | 1 | 8.80 |
| CHEMBL76237 | — | — | 1 | 8.68 |
| CHEMBL4064950 | — | — | 1 | 8.60 |
| CHEMBL212063 | — | — | 1 | 7.68 |
| CHEMBL434365 | — | — | 1 | 7.42 |
| CHEMBL4063897 | — | — | 1 | 7.31 |
| CHEMBL209383 | — | — | 1 | 7.30 |
| CHEMBL415046 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165520 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL76237 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL4064950 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL212063 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL434365 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL4063897 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL209383 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL415046 | — | Ki | = | 70.0 | nM | 7.16 |