Assay Detail
Binding
CHEMBL4010152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human Dopamine D4 receptor expressed in CHO cell membranes after 2 hrs by scintillation counting analysis
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 8.10 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098803 | — | — | 1 | 9.16 |
| CHEMBL4060461 | — | — | 2 | 9.14 |
| CHEMBL4078348 | — | — | 1 | 8.92 |
| CHEMBL4063235 | — | — | 1 | 8.89 |
| CHEMBL4097330 | — | — | 1 | 8.82 |
| CHEMBL4098859 | — | — | 1 | 8.70 |
| CHEMBL4090208 | — | — | 1 | 8.66 |
| CHEMBL4067439 | — | — | 1 | 8.37 |
| CHEMBL4069145 | — | — | 1 | 8.33 |
| CHEMBL4079301 | — | — | 1 | 8.28 |
| CHEMBL4071868 | — | — | 1 | 8.19 |
| CHEMBL4098236 | — | — | 1 | 8.15 |
| CHEMBL4105030 | — | — | 1 | 8.11 |
| CHEMBL4071185 | — | — | 1 | 8.10 |
| CHEMBL4096353 | — | — | 1 | 8.09 |
| CHEMBL4072821 | — | — | 1 | 7.96 |
| CHEMBL4080762 | — | — | 1 | 7.89 |
| CHEMBL4063282 | — | — | 1 | 7.85 |
| CHEMBL4091155 | — | — | 1 | 7.85 |
| CHEMBL4070091 | — | — | 1 | 7.77 |
| CHEMBL4087187 | — | — | 1 | 7.72 |
| CHEMBL4099711 | — | — | 1 | 7.68 |
| CHEMBL4060403 | — | — | 1 | 7.52 |
| CHEMBL4069091 | — | — | 1 | 7.51 |
| CHEMBL4091064 | — | — | 1 | 7.50 |
| CHEMBL4088639 | — | — | 1 | 7.47 |
| CHEMBL4102616 | — | — | 1 | 7.27 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.09 |
| CHEMBL4094869 | — | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098803 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL4060461 | — | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL4078348 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL4063235 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4060461 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4097330 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4098859 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4090208 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL4067439 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL4069145 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL4079301 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL4071868 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL4098236 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL4105030 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL4071185 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL4096353 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL4072821 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4080762 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4091155 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4063282 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4070091 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4087187 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL4099711 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL4060403 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4069091 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL4091064 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL4088639 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL4102616 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL4094869 | — | Ki | = | 84.0 | nM | 7.08 |