Assay Detail
Binding
CHEMBL4010153
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human Dopamine D2S receptor expressed in CHO cell membranes after 2 hrs by scintillation counting analysis
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 8.74 | 10.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4060461 | — | — | 2 | 10.03 |
| CHEMBL4063235 | — | — | 1 | 9.80 |
| CHEMBL4060403 | — | — | 1 | 9.39 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.35 |
| CHEMBL4069091 | — | — | 1 | 9.30 |
| CHEMBL4096353 | — | — | 1 | 9.28 |
| CHEMBL4091064 | — | — | 1 | 9.28 |
| CHEMBL4070091 | — | — | 1 | 9.26 |
| CHEMBL4078348 | — | — | 1 | 9.15 |
| CHEMBL4098803 | — | — | 1 | 9.13 |
| CHEMBL4097330 | — | — | 1 | 9.12 |
| CHEMBL4071868 | — | — | 1 | 9.08 |
| CHEMBL4098859 | — | — | 1 | 9.06 |
| CHEMBL4090208 | — | — | 1 | 9.05 |
| CHEMBL4071185 | — | — | 1 | 9.03 |
| CHEMBL4088639 | — | — | 1 | 8.82 |
| CHEMBL4069145 | — | — | 1 | 8.77 |
| CHEMBL4105030 | — | — | 1 | 8.72 |
| CHEMBL4098236 | — | — | 1 | 8.64 |
| CHEMBL4087187 | — | — | 1 | 8.26 |
| CHEMBL4099711 | — | — | 1 | 8.24 |
| CHEMBL4072821 | — | — | 1 | 8.13 |
| CHEMBL4067439 | — | — | 1 | 8.11 |
| CHEMBL4091155 | — | — | 1 | 8.11 |
| CHEMBL4079301 | — | — | 1 | 7.92 |
| CHEMBL4080762 | — | — | 1 | 7.85 |
| CHEMBL4063282 | — | — | 1 | 7.44 |
| CHEMBL4094869 | — | — | 1 | 7.41 |
| CHEMBL4102616 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4060461 | — | Ki | = | 0.094 | nM | 10.03 |
| CHEMBL4063235 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL4060403 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL4069091 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4096353 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL4091064 | — | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL4070091 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL4078348 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4060461 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL4098803 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL4097330 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL4071868 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL4098859 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL4090208 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4071185 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL4088639 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4069145 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4105030 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL4098236 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL4087187 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL4099711 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL4072821 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL4091155 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL4067439 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL4079301 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4080762 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4063282 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL4094869 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL4102616 | — | Ki | = | 48.0 | nM | 7.32 |