Assay Detail
Binding
CHEMBL4010244
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.76 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL4097153 | — | — | 1 | 8.17 |
| CHEMBL4080804 | — | — | 1 | 8.07 |
| CHEMBL1363627 | — | — | 1 | 7.30 |
| CHEMBL4070147 | — | — | 1 | 7.04 |
| CHEMBL4072947 | — | — | 1 | - |
| CHEMBL4074004 | — | — | 1 | - |
| CHEMBL4094554 | — | — | 1 | - |
| CHEMBL4084329 | — | — | 1 | - |
| CHEMBL4102291 | — | — | 1 | - |
| CHEMBL4080884 | — | — | 1 | - |
| CHEMBL4098919 | — | — | 1 | - |
| CHEMBL4081575 | — | — | 1 | - |
| CHEMBL4059623 | — | — | 1 | - |
| CHEMBL4089446 | — | — | 1 | - |
| CHEMBL4068266 | — | — | 1 | - |
| CHEMBL4104861 | — | — | 1 | - |
| CHEMBL4086993 | — | — | 1 | - |
| CHEMBL4067239 | — | — | 1 | - |
| CHEMBL4094688 | — | — | 1 | - |
| CHEMBL1518113 | — | — | 1 | - |
| CHEMBL4091108 | — | — | 1 | - |
| CHEMBL4061487 | — | — | 1 | - |
| CHEMBL4083316 | — | — | 1 | - |
| CHEMBL4099828 | — | — | 1 | - |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4097153 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL4080804 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL1363627 | — | Ki | = | 49.9 | nM | 7.30 |
| CHEMBL4070147 | — | Ki | = | 91.5 | nM | 7.04 |
| CHEMBL4072947 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4074004 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4094554 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4084329 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4102291 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4080884 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4098919 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4081575 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4059623 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4089446 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4068266 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4104861 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4086993 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4067239 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4094688 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL1518113 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4091108 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4061487 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4083316 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL4099828 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 3.8 | nM | - |