Assay Detail
ADMET
CHEMBL4010336
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Inhibition of DHFR (unknown origin)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.96 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL398675 | — | — | 1 | 6.20 |
| CHEMBL4084161 | — | — | 1 | 5.85 |
| CHEMBL4075292 | — | — | 1 | 4.82 |
| CHEMBL4090641 | — | — | 1 | 4.60 |
| CHEMBL4068466 | — | — | 1 | 4.55 |
| CHEMBL255019 | — | — | 1 | 4.42 |
| CHEMBL4077061 | — | — | 1 | 4.28 |
| CHEMBL343543 | — | — | 1 | - |
| CHEMBL342595 | — | — | 1 | - |
| CHEMBL250231 | — | — | 1 | - |
| CHEMBL4072481 | — | — | 1 | - |
| CHEMBL251906 | — | — | 1 | - |
| CHEMBL4062544 | — | — | 1 | - |
| CHEMBL399673 | — | — | 1 | - |
| CHEMBL251428 | — | — | 1 | - |
| CHEMBL268354 | — | — | 1 | - |
| CHEMBL4061457 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL398675 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4084161 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4075292 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4090641 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4068466 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL255019 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4077061 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL343543 | — | IC50 | - | — | - | |
| CHEMBL342595 | — | IC50 | - | — | - | |
| CHEMBL250231 | — | IC50 | - | — | - | |
| CHEMBL4072481 | — | IC50 | - | — | - | |
| CHEMBL251906 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4062544 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL399673 | — | IC50 | - | — | - | |
| CHEMBL251428 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL268354 | — | IC50 | - | — | - | |
| CHEMBL4061457 | — | IC50 | > | 150000.0 | nM | - |