Assay Detail
ADMET
CHEMBL4010619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.39 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL549472 | — | — | 1 | 5.70 |
| CHEMBL1095671 | — | — | 1 | 5.66 |
| CHEMBL25948 | SHOGAOL | — | 1 | 5.54 |
| CHEMBL402978 | GINGEROL | -1.0 | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL549472 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1095671 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL25948 | SHOGAOL | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL402978 | GINGEROL | IC50 | = | 22100.0 | nM | 4.66 |