Assay Detail
Binding
CHEMBL4010719
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Inhibition of HCV genotype 1b wild-type NS5B RNA dependent RNA polymerase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.77 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4103669 | — | — | 1 | 7.34 |
| CHEMBL4093601 | — | — | 1 | 6.82 |
| CHEMBL3287609 | — | — | 1 | 6.54 |
| CHEMBL4067160 | GS-441326 | -1.0 | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4103669 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4093601 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3287609 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4067160 | GS-441326 | IC50 | = | 420.0 | nM | 6.38 |