Assay Detail
Binding
CHEMBL4010756
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to HCV 5'-Alexa488-labeled IRES domain 3 loop RNA at 5 degC after overnight incubation by fluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Internal ribosome entry site (IRES) (CHEMBL612412) ↗| Type | NUCLEIC-ACID |
| Organism | Hepacivirus hominis |
Publication
Assessment of new triplet forming artificial nucleobases as RNA ligands directed towards HCV IRES IIId loop.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 4.97 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097244 | — | — | 1 | 5.50 |
| CHEMBL4076836 | — | — | 1 | 5.29 |
| CHEMBL4299247 | — | — | 1 | 5.24 |
| CHEMBL4068375 | — | — | 1 | 5.07 |
| CHEMBL4092747 | — | — | 1 | 5.03 |
| CHEMBL4104947 | — | — | 1 | 4.97 |
| CHEMBL4087092 | — | — | 1 | 4.53 |
| CHEMBL4059720 | — | — | 1 | 4.09 |
| CHEMBL4093611 | — | — | 1 | - |
| CHEMBL4072913 | — | — | 1 | - |
| CHEMBL4081659 | — | — | 1 | - |
| CHEMBL4071107 | — | — | 1 | - |
| CHEMBL4102668 | — | — | 1 | - |
| CHEMBL4096823 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097244 | — | Kd | = | 3200.0 | nM | 5.50 |
| CHEMBL4076836 | — | Kd | = | 5100.0 | nM | 5.29 |
| CHEMBL4299247 | — | Kd | = | 5700.0 | nM | 5.24 |
| CHEMBL4068375 | — | Kd | = | 8600.0 | nM | 5.07 |
| CHEMBL4092747 | — | Kd | = | 9400.0 | nM | 5.03 |
| CHEMBL4104947 | — | Kd | = | 10800.0 | nM | 4.97 |
| CHEMBL4087092 | — | Kd | = | 29500.0 | nM | 4.53 |
| CHEMBL4059720 | — | Kd | = | 81500.0 | nM | 4.09 |
| CHEMBL4093611 | — | Kd | = | 102500.0 | nM | - |
| CHEMBL4072913 | — | Kd | = | 177000.0 | nM | - |
| CHEMBL4081659 | — | Kd | = | 136900.0 | nM | - |
| CHEMBL4071107 | — | Kd | - | — | - | |
| CHEMBL4102668 | — | Kd | - | — | - | |
| CHEMBL4096823 | — | Kd | - | — | - |