Assay Detail
Binding
CHEMBL4010766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to HCV 5'-Alexa488-labeled IRES domain 3 loop RNA at 20 degC after overnight incubation in presence of 50-fold excess of tRNA by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Internal ribosome entry site (IRES) (CHEMBL612412) ↗| Type | NUCLEIC-ACID |
| Organism | Hepacivirus hominis |
Publication
Assessment of new triplet forming artificial nucleobases as RNA ligands directed towards HCV IRES IIId loop.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 4.88 | 4.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4097244 | — | — | 1 | 4.98 |
| CHEMBL4104947 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4097244 | — | Kd | = | 10500.0 | nM | 4.98 |
| CHEMBL4104947 | — | Kd | = | 17100.0 | nM | 4.77 |