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Assay Detail

CHEMBL4010774

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of MMP12 (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Macrophage metalloelastase (CHEMBL4393)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of novel TACE inhibitors compatible with topical application.
Ouvry G, Berton Y, Bhurruth-Alcor Y, Bonnary L, Bouix-Peter C, Bouquet K, Bourotte M, Chambon S, Comino C, Deprez B, Duvert D, Duvert G, Hacini-Rachinel F, Harris CS, Luzy AP, Mathieu A, Millois C, Pascau J, Pinto A, Polge G, Reitz A, Reversé K, Rosignoli C, Taquet N, Hennequin LF.
Bioorg Med Chem Lett (2017) 27 : 1848 -1853
PubMed 28274635 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.03 6.03

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4102106 1 6.03

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4102106 IC50 = 930.0 nM 6.03