Assay Detail
Functional
CHEMBL4011246
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGF-induced invasion of human MDA-MB-231 cells by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isolation and characterization of diterpene glycosides from Siegesbeckia pubescens.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.53 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081948 | — | — | 1 | 6.57 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 6.42 |
| CHEMBL4098446 | — | — | 1 | 5.46 |
| CHEMBL4060043 | — | — | 1 | 4.61 |
| CHEMBL4097543 | — | — | 1 | 4.57 |
| CHEMBL4071414 | — | — | 1 | - |
| CHEMBL4079508 | — | — | 1 | - |
| CHEMBL4105670 | — | — | 1 | - |
| CHEMBL1076911 | DARUTIGENOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081948 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL98350 | LY-294002 | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4098446 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL4060043 | — | IC50 | = | 24820.0 | nM | 4.61 |
| CHEMBL4097543 | — | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL4071414 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4079508 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4105670 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1076911 | DARUTIGENOL | IC50 | > | 25000.0 | nM | - |