Assay Detail
Binding
CHEMBL4012542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methyl-coumarin as substrate incubated for 15 mins by fluorescence assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthetic Approaches to the New Drugs Approved During 2015.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.59 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650443 | TRELAGLIPTIN | 4.0 | 1 | 8.89 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650443 | TRELAGLIPTIN | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 5.3 | nM | 8.28 |