Assay Detail
Functional
CHEMBL4012812
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Antiviral activity against Human rhinovirus B14 harboring VP1 A150V/E276K double mutant infected in human HeLa Rh cells assessed as protection against virus induced cytopathic effect after 3 days by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | rhinovirus B14 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.62 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141157 | IMOCITRELVIR | 2.0 | 1 | 7.31 |
| CHEMBL2062774 | VAPENDAVIR | 2.0 | 1 | 6.75 |
| CHEMBL4086772 | — | — | 1 | 6.58 |
| CHEMBL29609 | PLECONARIL | 2.0 | 1 | 5.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141157 | IMOCITRELVIR | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2062774 | VAPENDAVIR | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4086772 | — | EC50 | = | 264.0 | nM | 6.58 |
| CHEMBL29609 | PLECONARIL | EC50 | = | 1493.0 | nM | 5.83 |