Assay Detail
Binding
CHEMBL4013053
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human C-terminal His-tagged acid ceramidase variant 1 expressed in HEK293 cells using fluorogenic substrate Rbm-14-12 preincubated for 30 mins followed by substrate addition measured after 1 hr by fluorogenic assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.17 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093029 | — | — | 1 | 9.05 |
| CHEMBL4103207 | — | — | 1 | 9.00 |
| CHEMBL4084295 | — | — | 1 | 8.89 |
| CHEMBL4092051 | — | — | 1 | 8.68 |
| CHEMBL4062592 | — | — | 1 | 8.66 |
| CHEMBL4075447 | — | — | 1 | 8.62 |
| CHEMBL4065362 | — | — | 1 | 8.62 |
| CHEMBL4100744 | — | — | 1 | 8.60 |
| CHEMBL4071239 | — | — | 1 | 8.39 |
| CHEMBL4075028 | — | — | 1 | 8.33 |
| CHEMBL66205 | — | — | 1 | 8.18 |
| CHEMBL4096883 | — | — | 1 | 8.15 |
| CHEMBL4089655 | — | — | 1 | 8.15 |
| CHEMBL4076230 | — | — | 1 | 8.08 |
| CHEMBL4101140 | — | — | 1 | 8.07 |
| CHEMBL4095461 | — | — | 1 | 8.00 |
| CHEMBL4094489 | — | — | 1 | 7.86 |
| CHEMBL4075846 | — | — | 1 | 7.83 |
| CHEMBL460499 | CARMOFUR | 2.0 | 1 | 7.68 |
| CHEMBL4099796 | — | — | 1 | 7.68 |
| CHEMBL4076865 | — | — | 1 | 7.65 |
| CHEMBL4075647 | — | — | 1 | 7.53 |
| CHEMBL4077199 | — | — | 1 | 7.25 |
| CHEMBL4090927 | — | — | 1 | 7.17 |
| CHEMBL4081779 | — | — | 1 | - |
| CHEMBL4067955 | — | — | 1 | - |
| CHEMBL4092056 | — | — | 1 | - |
| CHEMBL4075570 | — | — | 1 | - |
| CHEMBL4084302 | — | — | 1 | - |
| CHEMBL4103996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093029 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4103207 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4084295 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4092051 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4062592 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4075447 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4065362 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4100744 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4071239 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4075028 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL66205 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4096883 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4089655 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4076230 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4101140 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL4095461 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4094489 | — | IC50 | = | 13.9 | nM | 7.86 |
| CHEMBL4075846 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL460499 | CARMOFUR | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL4099796 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4076865 | — | IC50 | = | 22.5 | nM | 7.65 |
| CHEMBL4075647 | — | IC50 | = | 29.3 | nM | 7.53 |
| CHEMBL4077199 | — | IC50 | = | 55.9 | nM | 7.25 |
| CHEMBL4090927 | — | IC50 | = | 68.4 | nM | 7.17 |
| CHEMBL4081779 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4067955 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4092056 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4075570 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4084302 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4103996 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4086076 | — | IC50 | > | 10000.0 | nM | - |