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Assay Detail

CHEMBL4013065

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to 5'-FAM labeled c-Myc Pu27 G-quadruplex DNA (unknown origin) in presence of K+ ions by MST analysis
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Not specified
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

New Disubstituted Quindoline Derivatives Inhibiting Burkitt's Lymphoma Cell Proliferation by Impeding c-MYC Transcription.
Liu HY, Chen AC, Yin QK, Li Z, Huang SM, Du G, He JH, Zan LP, Wang SK, Xu YH, Tan JH, Ou TM, Li D, Gu LQ, Huang ZS.
J Med Chem (2017) 60 : 5438 -5454
PubMed 28603988 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 17 - -
Kd 11 5.86 6.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4069072 1 6.16
CHEMBL4096330 1 6.10
CHEMBL4064871 1 5.89
CHEMBL4082247 1 5.89
CHEMBL4078040 1 5.89
CHEMBL4084715 1 5.89
CHEMBL4062064 1 5.89
CHEMBL4085912 1 5.89
CHEMBL4072958 1 5.89
CHEMBL4086338 1 5.89
CHEMBL219728 1 5.11
CHEMBL4074484 1 -
CHEMBL4094258 1 -
CHEMBL4076157 1 -
CHEMBL4060385 1 -
CHEMBL4084770 1 -
CHEMBL4071733 1 -
CHEMBL4070076 1 -
CHEMBL4063117 1 -
CHEMBL4080744 1 -
CHEMBL4098788 1 -
CHEMBL4099690 1 -
CHEMBL4069593 1 -
CHEMBL4063706 1 -
CHEMBL4069034 1 -
CHEMBL4074591 1 -
CHEMBL4092522 1 -
CHEMBL4091046 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4069072 Kd = 700.0 nM 6.16
CHEMBL4096330 Kd = 800.0 nM 6.10
CHEMBL4064871 Kd = 1300.0 nM 5.89
CHEMBL4082247 Kd = 1300.0 nM 5.89
CHEMBL4078040 Kd = 1300.0 nM 5.89
CHEMBL4084715 Kd = 1300.0 nM 5.89
CHEMBL4062064 Kd = 1300.0 nM 5.89
CHEMBL4085912 Kd = 1300.0 nM 5.89
CHEMBL4072958 Kd = 1300.0 nM 5.89
CHEMBL4086338 Kd = 1300.0 nM 5.89
CHEMBL219728 Kd = 7800.0 nM 5.11
CHEMBL4074484 Activity - -
CHEMBL4094258 Activity - -
CHEMBL4076157 Activity - -
CHEMBL4060385 Activity - -
CHEMBL4084770 Activity - -
CHEMBL4071733 Activity - -
CHEMBL4070076 Activity - -
CHEMBL4063117 Activity - -
CHEMBL4080744 Activity - -
CHEMBL4098788 Activity - -
CHEMBL4099690 Activity - -
CHEMBL4069593 Activity - -
CHEMBL4063706 Activity - -
CHEMBL4069034 Activity - -
CHEMBL4074591 Activity - -
CHEMBL4092522 Activity - -
CHEMBL4091046 Activity - -