Assay Detail
Functional
CHEMBL4013176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MDA-MB-231 cells after 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.83 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177757 | — | — | 1 | 5.17 |
| CHEMBL4087349 | — | — | 1 | 5.09 |
| CHEMBL4061000 | — | — | 1 | 5.05 |
| CHEMBL4082885 | — | — | 1 | 4.97 |
| CHEMBL4090687 | — | — | 1 | 4.87 |
| CHEMBL4072390 | — | — | 1 | 4.82 |
| CHEMBL4099331 | — | — | 1 | 4.58 |
| CHEMBL4080388 | — | — | 1 | 4.54 |
| CHEMBL4098413 | — | — | 1 | 4.38 |
| CHEMBL4074218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177757 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4087349 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4061000 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4082885 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4090687 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4072390 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL4099331 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL4080388 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL4098413 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4074218 | — | IC50 | > | 50000.0 | nM | - |