Assay Detail
Binding
CHEMBL4013206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged KGA S384A mutant expressed in Escherichia coli BL21(DE3)pLysS using glutamine substrate preincubated for 10 mins followed by substrate addition measured after 60 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.95 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177757 | — | — | 1 | 7.19 |
| CHEMBL4090687 | — | — | 1 | 7.11 |
| CHEMBL4074218 | — | — | 1 | 7.06 |
| CHEMBL4098413 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177757 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4090687 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4074218 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4098413 | — | IC50 | = | 361.0 | nM | 6.44 |