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Assay Detail

CHEMBL4013298

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Antagonist activity at adenosine transporter (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Lorthiois E, Anderson K, Vulpetti A, Rogel O, Cumin F, Ostermann N, Steinbacher S, Mac Sweeney A, Delgado O, Liao SM, Randl S, Rüdisser S, Dussauge S, Fettis K, Kieffer L, de Erkenez A, Yang L, Hartwieg C, Argikar UA, La Bonte LR, Newton R, Kansara V, Flohr S, Hommel U, Jaffee B, Maibaum J.
J Med Chem (2017) 60 : 5717 -5735
PubMed 28621538 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.38 5.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3908849 1 5.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3908849 IC50 = 4200.0 nM 5.38