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Assay Detail

CHEMBL4013632

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antispasmodial activity against multidrug-resistant asexual blood stages of Plasmodium falciparum Dd2 after 72 hrs by HRP2-based ELISA
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally.
Leven M, Knaab TC, Held J, Duffy S, Meister S, Fischli C, Meitzner D, Lehmann U, Lungerich B, Kuna K, Stahlke P, Delves MJ, Buchholz M, Winzeler EA, Avery VM, Mordmüller B, Wittlin S, Kurz T.
J Med Chem (2017) 60 : 6036 -6044
PubMed 28653845 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 7.93 9.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4079443 1 9.01
CHEMBL3335118 1 8.94
CHEMBL361497 ARTESUNATE 4.0 1 8.70
CHEMBL4070451 1 8.60
CHEMBL4081080 1 8.54
CHEMBL4089890 1 8.48
CHEMBL4097476 1 8.47
CHEMBL4100035 1 8.27
CHEMBL4105332 1 8.21
CHEMBL172 (S,R)-MEFLOQUINE 1 8.18
CHEMBL4061826 1 8.04
CHEMBL4067581 1 7.92
CHEMBL4097624 1 7.86
CHEMBL4078484 1 7.44
CHEMBL4082026 1 7.36
CHEMBL4077995 1 7.04
CHEMBL4102760 1 6.85
CHEMBL76 CHLOROQUINE 4.0 1 6.65
CHEMBL4083647 1 6.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4079443 IC50 = 0.97 nM 9.01
CHEMBL3335118 IC50 = 1.14 nM 8.94
CHEMBL361497 ARTESUNATE IC50 = 2.0 nM 8.70
CHEMBL4070451 IC50 = 2.5 nM 8.60
CHEMBL4081080 IC50 = 2.9 nM 8.54
CHEMBL4089890 IC50 = 3.3 nM 8.48
CHEMBL4097476 IC50 = 3.4 nM 8.47
CHEMBL4100035 IC50 = 5.4 nM 8.27
CHEMBL4105332 IC50 = 6.1 nM 8.21
CHEMBL172 (S,R)-MEFLOQUINE IC50 = 6.6 nM 8.18
CHEMBL4061826 IC50 = 9.2 nM 8.04
CHEMBL4067581 IC50 = 12.0 nM 7.92
CHEMBL4097624 IC50 = 13.8 nM 7.86
CHEMBL4078484 IC50 = 36.0 nM 7.44
CHEMBL4082026 IC50 = 44.0 nM 7.36
CHEMBL4077995 IC50 = 92.0 nM 7.04
CHEMBL4102760 IC50 = 140.0 nM 6.85
CHEMBL76 CHLOROQUINE IC50 = 224.7 nM 6.65
CHEMBL4083647 IC50 = 720.0 nM 6.14