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Assay Detail

CHEMBL4013633

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human HepG2 cells by CellTiterGlo assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally.
Leven M, Knaab TC, Held J, Duffy S, Meister S, Fischli C, Meitzner D, Lehmann U, Lungerich B, Kuna K, Stahlke P, Delves MJ, Buchholz M, Winzeler EA, Avery VM, Mordmüller B, Wittlin S, Kurz T.
J Med Chem (2017) 60 : 6036 -6044
PubMed 28653845 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.82 5.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4082026 1 5.43
CHEMBL4077995 1 5.12
CHEMBL4061826 1 5.08
CHEMBL4100035 1 5.08
CHEMBL4067581 1 5.07
CHEMBL4105332 1 4.87
CHEMBL4089890 1 4.84
CHEMBL4097476 1 4.84
CHEMBL4078484 1 4.78
CHEMBL4079443 1 4.78
CHEMBL4102760 1 4.59
CHEMBL4083647 1 4.56
CHEMBL4081080 1 4.56
CHEMBL4097624 1 4.37
CHEMBL4070451 1 4.36
CHEMBL76 CHLOROQUINE 4.0 1 -
CHEMBL3335118 1 -
CHEMBL361497 ARTESUNATE 4.0 1 -
CHEMBL172 (S,R)-MEFLOQUINE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4082026 IC50 = 3700.0 nM 5.43
CHEMBL4077995 IC50 = 7600.0 nM 5.12
CHEMBL4061826 IC50 = 8400.0 nM 5.08
CHEMBL4100035 IC50 = 8400.0 nM 5.08
CHEMBL4067581 IC50 = 8600.0 nM 5.07
CHEMBL4105332 IC50 = 13400.0 nM 4.87
CHEMBL4089890 IC50 = 14300.0 nM 4.84
CHEMBL4097476 IC50 = 14300.0 nM 4.84
CHEMBL4078484 IC50 = 16600.0 nM 4.78
CHEMBL4079443 IC50 = 16700.0 nM 4.78
CHEMBL4102760 IC50 = 25400.0 nM 4.59
CHEMBL4083647 IC50 = 27400.0 nM 4.56
CHEMBL4081080 IC50 = 27700.0 nM 4.56
CHEMBL4097624 IC50 = 42800.0 nM 4.37
CHEMBL4070451 IC50 = 43800.0 nM 4.36
CHEMBL76 CHLOROQUINE IC50 - -
CHEMBL3335118 IC50 > 10000.0 nM -
CHEMBL361497 ARTESUNATE IC50 - -
CHEMBL172 (S,R)-MEFLOQUINE IC50 - -