Assay Detail
Binding
CHEMBL4013657
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.70 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081080 | — | — | 1 | 7.17 |
| CHEMBL1107 | HALOFANTRINE | 4.0 | 1 | 6.81 |
| CHEMBL38827 | LUMEFANTRINE | 4.0 | 1 | 6.42 |
| CHEMBL4105332 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081080 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1107 | HALOFANTRINE | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL38827 | LUMEFANTRINE | IC50 | = | 377.0 | nM | 6.42 |
| CHEMBL4105332 | — | IC50 | = | 390.0 | nM | 6.41 |