Assay Detail
Functional
CHEMBL4013660
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 ring stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based confocal microscopic method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3-Hydroxy-N'-arylidenepropanehydrazonamides with Halo-Substituted Phenanthrene Scaffolds Cure P. berghei Infected Mice When Administered Perorally.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.39 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.52 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.77 |
| CHEMBL4070451 | — | — | 1 | 7.44 |
| CHEMBL4081080 | — | — | 1 | 7.18 |
| CHEMBL4105332 | — | — | 1 | 6.96 |
| CHEMBL4097624 | — | — | 1 | 6.46 |
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4070451 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4081080 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4105332 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4097624 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL1450 | ATOVAQUONE | IC50 | - | — | - |