Assay Detail
Binding
CHEMBL4013762
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at tTA containing TEV cleavage site-fused 5-HT2C-INI receptor isoform (unknown origin) expressed in TEV-fused beta-arrestin2 expressing HEK cells assessed as induction of beta-arrestin2 recruitment after 20 hrs by Tango assay
11
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of N-Substituted (2-Phenylcyclopropyl)methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 7.60 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091672 | — | — | 2 | 7.96 |
| CHEMBL39 | SEROTONIN | 3.0 | 2 | 7.82 |
| CHEMBL4063893 | — | — | 2 | 7.64 |
| CHEMBL360328 | LORCASERIN | 4.0 | 2 | 7.40 |
| CHEMBL4072722 | — | — | 2 | 7.16 |
| CHEMBL4101194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091672 | — | EC50 | = | 10.96 | nM | 7.96 |
| CHEMBL4091672 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL39 | SEROTONIN | EC50 | = | 15.14 | nM | 7.82 |
| CHEMBL39 | SEROTONIN | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4063893 | — | EC50 | = | 22.91 | nM | 7.64 |
| CHEMBL4063893 | — | EC50 | = | 22.7 | nM | 7.64 |
| CHEMBL360328 | LORCASERIN | EC50 | = | 39.81 | nM | 7.40 |
| CHEMBL360328 | LORCASERIN | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4072722 | — | EC50 | = | 69.18 | nM | 7.16 |
| CHEMBL4072722 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4101194 | — | EC50 | > | 1000.0 | nM | - |