Assay Detail
Binding
CHEMBL4013792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human carbonic anhydrase 9 preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold To Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.56 | 8.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096515 | — | — | 1 | 8.34 |
| CHEMBL214809 | — | — | 1 | 8.16 |
| CHEMBL217551 | — | — | 1 | 8.15 |
| CHEMBL307267 | — | — | 1 | 8.11 |
| CHEMBL432748 | — | — | 1 | 8.10 |
| CHEMBL217519 | — | — | 1 | 8.10 |
| CHEMBL77569 | — | — | 1 | 8.09 |
| CHEMBL2047397 | — | — | 1 | 8.09 |
| CHEMBL387402 | — | — | 1 | 8.09 |
| CHEMBL386418 | — | — | 1 | 8.08 |
| CHEMBL385438 | — | — | 1 | 8.08 |
| CHEMBL2047398 | — | — | 1 | 8.01 |
| CHEMBL4064657 | — | — | 1 | 7.75 |
| CHEMBL2047401 | — | — | 1 | 7.66 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.59 |
| CHEMBL4103342 | — | — | 1 | 7.57 |
| CHEMBL310286 | — | — | 1 | 7.48 |
| CHEMBL4073247 | — | — | 1 | 7.37 |
| CHEMBL311831 | — | — | 1 | 7.37 |
| CHEMBL4061981 | — | — | 1 | 7.32 |
| CHEMBL384572 | — | — | 1 | 7.23 |
| CHEMBL4085415 | — | — | 1 | 7.20 |
| CHEMBL4080010 | — | — | 1 | 7.19 |
| CHEMBL4104242 | — | — | 1 | 7.16 |
| CHEMBL80594 | — | — | 1 | 7.16 |
| CHEMBL4105134 | — | — | 1 | 7.13 |
| CHEMBL4100086 | — | — | 1 | 6.68 |
| CHEMBL4087893 | — | — | 1 | 6.56 |
| CHEMBL4094954 | — | — | 1 | 6.52 |
| CHEMBL183852 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096515 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL214809 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL217551 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL307267 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL432748 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL217519 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL77569 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL2047397 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL387402 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL386418 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL385438 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL2047398 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL4064657 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2047401 | — | Ki | = | 22.1 | nM | 7.66 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.4 | nM | 7.59 |
| CHEMBL4103342 | — | Ki | = | 26.7 | nM | 7.57 |
| CHEMBL310286 | — | Ki | = | 33.3 | nM | 7.48 |
| CHEMBL4073247 | — | Ki | = | 42.8 | nM | 7.37 |
| CHEMBL311831 | — | Ki | = | 43.1 | nM | 7.37 |
| CHEMBL4061981 | — | Ki | = | 48.2 | nM | 7.32 |
| CHEMBL384572 | — | Ki | = | 58.8 | nM | 7.23 |
| CHEMBL4085415 | — | Ki | = | 62.5 | nM | 7.20 |
| CHEMBL4080010 | — | Ki | = | 64.8 | nM | 7.19 |
| CHEMBL4104242 | — | Ki | = | 69.5 | nM | 7.16 |
| CHEMBL80594 | — | Ki | = | 69.7 | nM | 7.16 |
| CHEMBL4105134 | — | Ki | = | 74.9 | nM | 7.13 |
| CHEMBL4100086 | — | Ki | = | 208.2 | nM | 6.68 |
| CHEMBL4087893 | — | Ki | = | 272.6 | nM | 6.56 |
| CHEMBL4094954 | — | Ki | = | 300.6 | nM | 6.52 |
| CHEMBL183852 | — | Ki | = | 480.0 | nM | 6.32 |