Assay Detail
Unclassified
CHEMBL4013835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Chemical reactivity of the compound assessed as BME adduct formation after 2 hrs by LC-MS analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Unclassified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 4.37 | 4.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089842 | — | — | 1 | 4.37 |
| CHEMBL4099992 | — | — | 1 | 4.37 |
| CHEMBL4064081 | — | — | 1 | - |
| CHEMBL4068509 | PRN-1371 | 1.0 | 1 | - |
| CHEMBL4095844 | — | — | 1 | - |
| CHEMBL4061766 | — | — | 1 | - |
| CHEMBL4081984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089842 | — | Kd | = | 43000.0 | nM | 4.37 |
| CHEMBL4099992 | — | Kd | = | 43000.0 | nM | 4.37 |
| CHEMBL4064081 | — | Kd | = | 291000.0 | nM | - |
| CHEMBL4068509 | PRN-1371 | Kd | = | 164000.0 | nM | - |
| CHEMBL4095844 | — | Kd | = | 933000.0 | nM | - |
| CHEMBL4061766 | — | Kd | = | 4140000.0 | nM | - |
| CHEMBL4081984 | — | Kd | = | 951000.0 | nM | - |