Assay Detail
ADMET
CHEMBL4013941
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Cytotoxicity against NHDF assessed as reduction in cell viability after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | NHDF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Potent Reversible and Irreversible Myeloperoxidase Inhibitors Using Virtual Screening Procedure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.77 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL581893 | — | — | 1 | 4.77 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | - |
| CHEMBL276832 | HYDRALAZINE | 4.0 | 1 | - |
| CHEMBL4098081 | — | — | 1 | - |
| CHEMBL251689 | — | — | 1 | - |
| CHEMBL4064328 | — | — | 1 | - |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | - |
| CHEMBL4098162 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL581893 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL50 | QUERCETIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL276832 | HYDRALAZINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL4098081 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL251689 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4064328 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | > | 50000.0 | nM | - |
| CHEMBL4098162 | — | IC50 | > | 50000.0 | nM | - |