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Assay Detail

CHEMBL4013952

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Norovirus 3CL protease using Edans-DFHLQ/GP-Dabcyl as substrate after 30 mins by FRET assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Norovirus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease.
Galasiti Kankanamalage AC, Kim Y, Rathnayake AD, Alliston KR, Butler MM, Cardinale SC, Bowlin TL, Groutas WC, Chang KO.
J Med Chem (2017) 60 : 6239 -6248
PubMed 28671827 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.94 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4104187 1 7.10
CHEMBL3427141 1 7.00
CHEMBL4078413 1 7.00
CHEMBL4096457 1 7.00
CHEMBL3427143 1 7.00
CHEMBL4088757 1 6.52
CHEMBL4105106 1 6.40
CHEMBL4060210 1 6.30
CHEMBL4097398 1 6.22
CHEMBL3427166 1 6.10
CHEMBL4070221 1 6.10
CHEMBL4061226 1 6.10
CHEMBL4067510 1 6.05
CHEMBL4069889 1 5.75
CHEMBL4083097 1 5.60
CHEMBL4068460 1 5.55
CHEMBL4097319 1 5.52
CHEMBL4090885 1 5.51
CHEMBL4086271 1 5.46
CHEMBL4089599 1 5.46
CHEMBL4059802 1 5.43
CHEMBL4079289 1 5.14
CHEMBL4080873 1 5.12
CHEMBL4081729 1 5.12
CHEMBL4088437 1 4.99
CHEMBL4098228 1 4.98

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4104187 IC50 = 80.0 nM 7.10
CHEMBL3427141 IC50 = 100.0 nM 7.00
CHEMBL4078413 IC50 = 100.0 nM 7.00
CHEMBL4096457 IC50 = 100.0 nM 7.00
CHEMBL3427143 IC50 = 100.0 nM 7.00
CHEMBL4088757 IC50 = 300.0 nM 6.52
CHEMBL4105106 IC50 = 400.0 nM 6.40
CHEMBL4060210 IC50 = 500.0 nM 6.30
CHEMBL4097398 IC50 = 600.0 nM 6.22
CHEMBL3427166 IC50 = 800.0 nM 6.10
CHEMBL4070221 IC50 = 800.0 nM 6.10
CHEMBL4061226 IC50 = 800.0 nM 6.10
CHEMBL4067510 IC50 = 900.0 nM 6.05
CHEMBL4069889 IC50 = 1800.0 nM 5.75
CHEMBL4083097 IC50 = 2500.0 nM 5.60
CHEMBL4068460 IC50 = 2800.0 nM 5.55
CHEMBL4097319 IC50 = 3000.0 nM 5.52
CHEMBL4090885 IC50 = 3100.0 nM 5.51
CHEMBL4086271 IC50 = 3500.0 nM 5.46
CHEMBL4089599 IC50 = 3500.0 nM 5.46
CHEMBL4059802 IC50 = 3700.0 nM 5.43
CHEMBL4079289 IC50 = 7200.0 nM 5.14
CHEMBL4080873 IC50 = 7500.0 nM 5.12
CHEMBL4081729 IC50 = 7500.0 nM 5.12
CHEMBL4088437 IC50 = 10200.0 nM 4.99
CHEMBL4098228 IC50 = 10500.0 nM 4.98