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Assay Detail

CHEMBL4013953

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Norovirus infected in human HG23 cells assessed as inhibition of viral replication after 48 hrs by quantitative RT-PCR method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Norovirus
Confidence 1 — Organism
Curated By Autocuration

Target

Norovirus (CHEMBL4296584)
Type ORGANISM
Organism Norovirus

Publication

Design, Synthesis, and Evaluation of Novel Prodrugs of Transition State Inhibitors of Norovirus 3CL Protease.
Galasiti Kankanamalage AC, Kim Y, Rathnayake AD, Alliston KR, Butler MM, Cardinale SC, Bowlin TL, Groutas WC, Chang KO.
J Med Chem (2017) 60 : 6239 -6248
PubMed 28671827 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 26 6.91 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4096457 1 7.82
CHEMBL3427141 1 7.70
CHEMBL3427143 1 7.70
CHEMBL4105106 1 7.70
CHEMBL4078413 1 7.60
CHEMBL4061226 1 7.60
CHEMBL4070221 1 7.60
CHEMBL4088757 1 7.52
CHEMBL4104187 1 7.52
CHEMBL4067510 1 7.52
CHEMBL4060210 1 7.40
CHEMBL4097398 1 7.22
CHEMBL4088437 1 6.70
CHEMBL4080873 1 6.70
CHEMBL4069889 1 6.52
CHEMBL3427166 1 6.52
CHEMBL4086271 1 6.52
CHEMBL4068460 1 6.52
CHEMBL4090885 1 6.40
CHEMBL4083097 1 6.40
CHEMBL4097319 1 6.30
CHEMBL4098228 1 6.22
CHEMBL4081729 1 6.16
CHEMBL4079289 1 6.10
CHEMBL4059802 1 5.89
CHEMBL4089599 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4096457 EC50 = 15.0 nM 7.82
CHEMBL3427141 EC50 = 20.0 nM 7.70
CHEMBL3427143 EC50 = 20.0 nM 7.70
CHEMBL4105106 EC50 = 20.0 nM 7.70
CHEMBL4078413 EC50 = 25.0 nM 7.60
CHEMBL4061226 EC50 = 25.0 nM 7.60
CHEMBL4070221 EC50 = 25.0 nM 7.60
CHEMBL4088757 EC50 = 30.0 nM 7.52
CHEMBL4104187 EC50 = 30.0 nM 7.52
CHEMBL4067510 EC50 = 30.0 nM 7.52
CHEMBL4060210 EC50 = 40.0 nM 7.40
CHEMBL4097398 EC50 = 60.0 nM 7.22
CHEMBL4088437 EC50 = 200.0 nM 6.70
CHEMBL4080873 EC50 = 200.0 nM 6.70
CHEMBL4069889 EC50 = 300.0 nM 6.52
CHEMBL3427166 EC50 = 300.0 nM 6.52
CHEMBL4086271 EC50 = 300.0 nM 6.52
CHEMBL4068460 EC50 = 300.0 nM 6.52
CHEMBL4090885 EC50 = 400.0 nM 6.40
CHEMBL4083097 EC50 = 400.0 nM 6.40
CHEMBL4097319 EC50 = 500.0 nM 6.30
CHEMBL4098228 EC50 = 600.0 nM 6.22
CHEMBL4081729 EC50 = 700.0 nM 6.16
CHEMBL4079289 EC50 = 800.0 nM 6.10
CHEMBL4059802 EC50 = 1300.0 nM 5.89
CHEMBL4089599 EC50 = 1400.0 nM 5.85