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Assay Detail

CHEMBL4014619

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of cysteinyl leukotriene receptor in guinea pig trachea strip assessed as inhibition of LTD4-induced trachea strip contraction preincubated for 2 mins followed by LTD4 induction
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.
Proschak E, Heitel P, Kalinowsky L, Merk D.
J Med Chem (2017) 60 : 5235 -5266
PubMed 28252961 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.05 5.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL173443 1 5.05
CHEMBL173278 1 5.05
CHEMBL174471 1 5.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL173443 IC50 = 9000.0 nM 5.05
CHEMBL173278 IC50 = 9000.0 nM 5.05
CHEMBL174471 IC50 = 9000.0 nM 5.05