Assay Detail
Functional
CHEMBL4014696
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Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by CellTiter-Glo luminescent assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and formulation studies of griseofulvin analogues with improved solubility and metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.33 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069643 | — | — | 1 | 5.85 |
| CHEMBL521969 | — | — | 1 | 5.77 |
| CHEMBL491114 | — | — | 1 | 5.77 |
| CHEMBL4096861 | — | — | 1 | 5.50 |
| CHEMBL1956512 | — | — | 1 | 5.48 |
| CHEMBL4101253 | — | — | 1 | 5.46 |
| CHEMBL4065895 | — | — | 1 | 5.28 |
| CHEMBL1956511 | — | — | 1 | 5.18 |
| CHEMBL4074525 | — | — | 1 | 5.15 |
| CHEMBL4093504 | — | — | 1 | 5.09 |
| CHEMBL4077900 | — | — | 1 | 4.77 |
| CHEMBL562 | GRISEOFULVIN | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069643 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL521969 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL491114 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4096861 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1956512 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4101253 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4065895 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL1956511 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4074525 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4093504 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4077900 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL562 | GRISEOFULVIN | IC50 | = | 25000.0 | nM | 4.60 |