Assay Detail
Functional
CHEMBL4014697
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Antiproliferative activity against human U2OS cells after 72 hrs by CellTiter-Glo luminescent assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2OS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and formulation studies of griseofulvin analogues with improved solubility and metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.50 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069643 | — | — | 1 | 5.92 |
| CHEMBL521969 | — | — | 1 | 5.89 |
| CHEMBL491114 | — | — | 1 | 5.89 |
| CHEMBL4074525 | — | — | 1 | 5.80 |
| CHEMBL4101253 | — | — | 1 | 5.72 |
| CHEMBL4096861 | — | — | 1 | 5.68 |
| CHEMBL1956512 | — | — | 1 | 5.58 |
| CHEMBL4065895 | — | — | 1 | 5.58 |
| CHEMBL1956511 | — | — | 1 | 5.25 |
| CHEMBL4093504 | — | — | 1 | 5.16 |
| CHEMBL4077900 | — | — | 1 | 4.86 |
| CHEMBL562 | GRISEOFULVIN | 4.0 | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069643 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL521969 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL491114 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4074525 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4101253 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4096861 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1956512 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4065895 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1956511 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4093504 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4077900 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL562 | GRISEOFULVIN | IC50 | = | 22400.0 | nM | 4.65 |