Assay Detail
Binding
CHEMBL4015012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 6-carboxyfluorescein succinimidyl ester fluorescence tagged-Bid BH3 peptide (79 to 99 residues) binding to Bcl-2 (unknown origin) after 30 mins by fluorescence polarization assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.30 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082302 | — | — | 1 | 6.85 |
| CHEMBL4098261 | — | — | 1 | 6.82 |
| CHEMBL4081347 | — | — | 1 | 6.77 |
| CHEMBL4062127 | — | — | 1 | 6.64 |
| CHEMBL4071224 | — | — | 1 | 6.57 |
| CHEMBL4097869 | — | — | 1 | 6.39 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.38 |
| CHEMBL4070752 | — | — | 1 | 6.33 |
| CHEMBL4067010 | — | — | 1 | 6.14 |
| CHEMBL4105602 | — | — | 1 | 6.12 |
| CHEMBL4094488 | — | — | 1 | 6.09 |
| CHEMBL4100319 | — | — | 1 | 6.07 |
| CHEMBL4088240 | — | — | 1 | 5.98 |
| CHEMBL4094073 | — | — | 1 | 5.92 |
| CHEMBL4073436 | — | — | 1 | 5.91 |
| CHEMBL4090152 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082302 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4098261 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4081347 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4062127 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL4071224 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL4097869 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL4070752 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL4067010 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL4105602 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL4094488 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL4100319 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL4088240 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL4094073 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL4073436 | — | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL4090152 | — | Ki | = | 1410.0 | nM | 5.85 |