Assay Detail
Binding
CHEMBL4015013
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 6-carboxyfluorescein succinimidyl ester fluorescence tagged-Bid BH3 peptide (79 to 99 residues) binding to Mcl-1 (unknown origin) after 30 mins by fluorescence polarization assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 5.82 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4105602 | — | — | 1 | 6.96 |
| CHEMBL4062127 | — | — | 1 | 6.85 |
| CHEMBL4082302 | — | — | 1 | 6.82 |
| CHEMBL4071224 | — | — | 1 | 6.70 |
| CHEMBL4097869 | — | — | 1 | 6.70 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 6.70 |
| CHEMBL4070752 | — | — | 1 | 6.60 |
| CHEMBL4081347 | — | — | 1 | 6.51 |
| CHEMBL4098261 | — | — | 1 | 6.44 |
| CHEMBL4067010 | — | — | 1 | 6.24 |
| CHEMBL4094073 | — | — | 1 | 6.13 |
| CHEMBL4088240 | — | — | 1 | 6.10 |
| CHEMBL4094488 | — | — | 1 | 6.05 |
| CHEMBL4100319 | — | — | 1 | 6.02 |
| CHEMBL4073436 | — | — | 1 | 5.92 |
| CHEMBL4101383 | — | — | 1 | 5.83 |
| CHEMBL4097987 | — | — | 1 | 5.82 |
| CHEMBL4090152 | — | — | 1 | 5.79 |
| CHEMBL4066811 | — | — | 1 | 5.73 |
| CHEMBL4083396 | — | — | 1 | 5.70 |
| CHEMBL4090685 | — | — | 1 | 5.68 |
| CHEMBL4060541 | — | — | 1 | 5.62 |
| CHEMBL4098490 | — | — | 1 | 5.59 |
| CHEMBL4082881 | — | — | 1 | 5.57 |
| CHEMBL4098411 | — | — | 1 | 5.52 |
| CHEMBL4079739 | — | — | 1 | 5.49 |
| CHEMBL4060999 | — | — | 1 | 5.47 |
| CHEMBL4095827 | — | — | 1 | 5.38 |
| CHEMBL4088098 | — | — | 1 | 5.36 |
| CHEMBL4085651 | — | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4105602 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4062127 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL4082302 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4071224 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4097869 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL51483 | GOSSYPOL | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4070752 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4081347 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL4098261 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL4067010 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL4094073 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL4088240 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL4094488 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL4100319 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL4073436 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL4101383 | — | Ki | = | 1490.0 | nM | 5.83 |
| CHEMBL4097987 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL4090152 | — | Ki | = | 1630.0 | nM | 5.79 |
| CHEMBL4066811 | — | Ki | = | 1870.0 | nM | 5.73 |
| CHEMBL4083396 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4090685 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL4060541 | — | Ki | = | 2380.0 | nM | 5.62 |
| CHEMBL4098490 | — | Ki | = | 2570.0 | nM | 5.59 |
| CHEMBL4082881 | — | Ki | = | 2680.0 | nM | 5.57 |
| CHEMBL4098411 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4079739 | — | Ki | = | 3240.0 | nM | 5.49 |
| CHEMBL4060999 | — | Ki | = | 3370.0 | nM | 5.47 |
| CHEMBL4095827 | — | Ki | = | 4130.0 | nM | 5.38 |
| CHEMBL4088098 | — | Ki | = | 4420.0 | nM | 5.36 |
| CHEMBL4085651 | — | Ki | = | 5380.0 | nM | 5.27 |
| CHEMBL4103583 | — | Ki | = | 7780.0 | nM | 5.11 |
| CHEMBL4098921 | — | Ki | = | 8190.0 | nM | 5.09 |
| CHEMBL4079962 | — | Ki | = | 9890.0 | nM | 5.00 |
| CHEMBL4077796 | — | Ki | = | 10260.0 | nM | 4.99 |
| CHEMBL4071936 | — | Ki | = | 11610.0 | nM | 4.93 |
| CHEMBL4069226 | — | Ki | = | 12530.0 | nM | 4.90 |
| CHEMBL4090275 | — | Ki | = | 12870.0 | nM | 4.89 |
| CHEMBL4069515 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL4060001 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL4080386 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL4094171 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL4069674 | — | Ki | > | 30000.0 | nM | - |