Assay Detail
Binding
CHEMBL4015094
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Inhibition of HIV1 3B dinucleoside reverse transcriptase infected in human P4R5 MAGI cells assessed as reduction in viral infection after 2 hrs by Galacto-Star beta-galactosidase reporter gene assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and anti-HIV activities of unsymmetrical long chain dicarboxylate esters of dinucleoside reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.60 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4073114 | — | — | 1 | 7.33 |
| CHEMBL4086202 | — | — | 1 | 7.00 |
| CHEMBL4099977 | — | — | 1 | 6.75 |
| CHEMBL4060692 | — | — | 1 | 6.70 |
| CHEMBL4092223 | — | — | 1 | 6.40 |
| CHEMBL105318 | ALOVUDINE | 2.0 | 1 | 6.10 |
| CHEMBL4064694 | — | — | 1 | 5.75 |
| CHEMBL885 | EMTRICITABINE | 4.0 | 1 | 5.72 |
| CHEMBL4084477 | — | — | 1 | 5.43 |
| CHEMBL4064527 | — | — | 1 | 4.85 |
| CHEMBL4083531 | — | — | 1 | 4.83 |
| CHEMBL4102428 | — | — | 1 | 4.79 |
| CHEMBL4088909 | — | — | 1 | 4.58 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 4.49 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 4.46 |
| CHEMBL4061753 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4073114 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4086202 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4099977 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4060692 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4092223 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL105318 | ALOVUDINE | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4064694 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL885 | EMTRICITABINE | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4084477 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4064527 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4083531 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4102428 | — | EC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL4088909 | — | EC50 | = | 26600.0 | nM | 4.58 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 32700.0 | nM | 4.49 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 34400.0 | nM | 4.46 |
| CHEMBL4061753 | — | EC50 | = | 44500.0 | nM | 4.35 |