Assay Detail
Binding
CHEMBL4015193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as peak current changes at +80 mV by whole cell patch-clamp method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Short transient receptor potential channel 6 (CHEMBL1795081) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.71 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4085233 | — | — | 1 | 6.05 |
| CHEMBL4060387 | — | — | 1 | 5.69 |
| CHEMBL1496110 | — | — | 1 | 5.60 |
| CHEMBL4060400 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085233 | — | EC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4060387 | — | EC50 | = | 2050.0 | nM | 5.69 |
| CHEMBL1496110 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4060400 | — | EC50 | = | 3240.0 | nM | 5.49 |