Assay Detail
Binding
CHEMBL4015195
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human TRPC7 expressed in HEK293 cells assessed as increase in intracellular calcium level measured for 2.5 mins in presence of 2 mM Ca2+ by Fluo8-AM dye-based fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Short transient receptor potential channel 7 (CHEMBL4105799) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.63 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4085233 | — | — | 1 | 7.05 |
| CHEMBL4060387 | — | — | 1 | 6.67 |
| CHEMBL4060400 | — | — | 1 | 6.50 |
| CHEMBL1496110 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085233 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4060387 | — | EC50 | = | 213.0 | nM | 6.67 |
| CHEMBL4060400 | — | EC50 | = | 314.0 | nM | 6.50 |
| CHEMBL1496110 | — | EC50 | = | 497.0 | nM | 6.30 |