Assay Detail
Binding
CHEMBL4015206
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse TRPC6 expressed in HEK293 cells co-expressing Gq11-PLCbeta fused M5 receptor assessed as induction of membrane potential depolarization measured for 2.5 mins by FLIPR assay
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Short transient receptor potential channel 6 (CHEMBL1795081) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.85 | 5.85 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1496110 | — | — | 2 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1496110 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1496110 | — | Activity | - | — | - |