Assay Detail
Binding
CHEMBL4015579
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Inhibition of HCV genotype 1b NS5B replicase C316N mutant infected in human HuH7 cells assessed as reduction of viral replication after 3 days by luciferase reporter assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 7.14 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093031 | BMS-929075 | 1.0 | 1 | 7.75 |
| CHEMBL4067259 | — | — | 1 | 7.50 |
| CHEMBL4088517 | — | — | 1 | 7.46 |
| CHEMBL4063673 | — | — | 1 | 7.34 |
| CHEMBL4104000 | — | — | 1 | 7.29 |
| CHEMBL4078188 | — | — | 1 | 7.26 |
| CHEMBL4086080 | — | — | 1 | 7.20 |
| CHEMBL4080649 | — | — | 1 | 7.20 |
| CHEMBL4091857 | — | — | 1 | 6.96 |
| CHEMBL4085288 | — | — | 1 | 6.86 |
| CHEMBL4104880 | — | — | 1 | 6.82 |
| CHEMBL4096241 | — | — | 1 | 6.71 |
| CHEMBL4071017 | — | — | 1 | 6.51 |
| CHEMBL4072654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093031 | BMS-929075 | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4067259 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4088517 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4063673 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4104000 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4078188 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4086080 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4080649 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4091857 | — | EC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4085288 | — | EC50 | = | 139.0 | nM | 6.86 |
| CHEMBL4104880 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4096241 | — | EC50 | = | 193.0 | nM | 6.71 |
| CHEMBL4071017 | — | EC50 | = | 308.0 | nM | 6.51 |
| CHEMBL4072654 | — | EC50 | - | — | - |