Assay Detail
Binding
CHEMBL4015580
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Inhibition of HCV genotype 1b NS5B replicase expressed in Escherichia coli BL21(DE3) using polyA/biotinylated oligo(dT12) as template/primer in presence of [3H]UTP after 60 mins by SPA assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.42 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072654 | — | — | 1 | 8.23 |
| CHEMBL4093370 | — | — | 1 | 8.10 |
| CHEMBL4068920 | — | — | 1 | 7.58 |
| CHEMBL4098643 | — | — | 1 | 7.39 |
| CHEMBL4090003 | — | — | 1 | 7.04 |
| CHEMBL4097730 | — | — | 1 | 6.92 |
| CHEMBL4071621 | — | — | 1 | 6.72 |
| CHEMBL4078065 | — | — | 1 | 6.44 |
| CHEMBL4102335 | — | — | 1 | 6.19 |
| CHEMBL4060248 | — | — | 1 | 6.11 |
| CHEMBL4085948 | — | — | 1 | 5.96 |
| CHEMBL4082149 | — | — | 1 | 5.66 |
| CHEMBL4079698 | — | — | 1 | 5.44 |
| CHEMBL4082472 | — | — | 1 | 5.24 |
| CHEMBL3902813 | — | — | 1 | 5.08 |
| CHEMBL4064415 | — | — | 1 | 4.68 |
| CHEMBL4067131 | — | — | 1 | - |
| CHEMBL4094593 | — | — | 1 | - |
| CHEMBL4060584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072654 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4093370 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4068920 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4098643 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4090003 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4097730 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4071621 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4078065 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4102335 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4060248 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4085948 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4082149 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4079698 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4082472 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3902813 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4064415 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL4067131 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4094593 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4060584 | — | IC50 | > | 50000.0 | nM | - |