Assay Detail
Functional
CHEMBL4015582
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 1a infected in human HuH7 cells after 3 days by luciferase reporter assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 7.50 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4063673 | — | — | 1 | 8.92 |
| CHEMBL4088517 | — | — | 1 | 8.68 |
| CHEMBL4104000 | — | — | 1 | 8.64 |
| CHEMBL4078188 | — | — | 1 | 8.55 |
| CHEMBL4093031 | BMS-929075 | 1.0 | 1 | 8.40 |
| CHEMBL4080649 | — | — | 1 | 8.21 |
| CHEMBL4067259 | — | — | 1 | 8.10 |
| CHEMBL4086080 | — | — | 1 | 8.08 |
| CHEMBL4091857 | — | — | 1 | 7.89 |
| CHEMBL4071017 | — | — | 1 | 7.82 |
| CHEMBL4104880 | — | — | 1 | 7.80 |
| CHEMBL4085288 | — | — | 1 | 7.77 |
| CHEMBL4096241 | — | — | 1 | 7.77 |
| CHEMBL4072654 | — | — | 1 | 7.44 |
| CHEMBL4093370 | — | — | 1 | 6.80 |
| CHEMBL4098643 | — | — | 1 | 6.62 |
| CHEMBL4068920 | — | — | 1 | 6.22 |
| CHEMBL4071621 | — | — | 1 | 6.20 |
| CHEMBL4060248 | — | — | 1 | 6.00 |
| CHEMBL4097730 | — | — | 1 | 5.85 |
| CHEMBL4090003 | — | — | 1 | 5.75 |
| CHEMBL4079698 | — | — | 1 | - |
| CHEMBL4085948 | — | — | 1 | - |
| CHEMBL4102335 | — | — | 1 | - |
| CHEMBL4082472 | — | — | 1 | - |
| CHEMBL4082149 | — | — | 1 | - |
| CHEMBL4064415 | — | — | 1 | - |
| CHEMBL3902813 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4063673 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4088517 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4104000 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4078188 | — | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4093031 | BMS-929075 | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4080649 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4067259 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4086080 | — | EC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4091857 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4071017 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4104880 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4085288 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4096241 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4072654 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4093370 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4098643 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4068920 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4071621 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4060248 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4097730 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4090003 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4079698 | — | EC50 | - | — | - | |
| CHEMBL4085948 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4102335 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4082472 | — | EC50 | - | — | - | |
| CHEMBL4082149 | — | EC50 | - | — | - | |
| CHEMBL4064415 | — | EC50 | > | 11000.0 | nM | - |
| CHEMBL3902813 | — | EC50 | - | — | - |