Assay Detail
ADMET
CHEMBL4015592
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of microsomal CYP2C8 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.07 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4086080 | — | — | 1 | 7.58 |
| CHEMBL4096241 | — | — | 1 | 6.46 |
| CHEMBL4078188 | — | — | 1 | 6.00 |
| CHEMBL4088517 | — | — | 1 | 5.82 |
| CHEMBL4104000 | — | — | 1 | 5.41 |
| CHEMBL4093031 | BMS-929075 | 1.0 | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4086080 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4096241 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4078188 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4088517 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4104000 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4093031 | BMS-929075 | IC50 | = | 6700.0 | nM | 5.17 |