Assay Detail

CHEMBL4015618

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Functional

Antiviral activity against HCV genotype 6a infected in human HuH7 cells after 3 days by luciferase reporter assay

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepacivirus hominis
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.

Yeung KS, Beno BR, Parcella K, Bender JA, Grant-Young KA, Nickel A, Gunaga P, Anjanappa P, Bora RO, Selvakumar K, Rigat K, Wang YK, Liu M, Lemm J, Mosure K, Sheriff S, Wan C, Witmer M, Kish K, Hanumegowda U, Zhuo X, Shu YZ, Parker D, Haskell R, Ng A, Gao Q, Colston E, Raybon J, Grasela DM, Santone K, Gao M, Meanwell NA, Sinz M, Soars MG, Knipe JO, Roberts SB, Kadow JF.
J Med Chem (2017) 60 : 4369 -4385
PubMed 28430437 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.30	8.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4093031	BMS-929075	1.0	1	8.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4093031	BMS-929075	EC50	=	5.0	nM	8.30