Assay Detail
Binding
CHEMBL4015769
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I] phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg-Pro-Arg-Tyr-NH2 from human recombinant vasopressin V1a receptor expressed in HEK293 after 2 hrs by liquid scintillation counting method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tolvaptan-Type Vasopressin Receptor Ligands: Important Role of Axial Chirality in the Active Form.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.40 | 8.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075127 | — | — | 1 | 8.99 |
| CHEMBL118271 | — | — | 1 | 8.80 |
| CHEMBL4104877 | — | — | 1 | 8.73 |
| CHEMBL4094707 | — | — | 1 | 8.69 |
| CHEMBL4064556 | — | — | 1 | 8.55 |
| CHEMBL4086079 | — | — | 1 | 8.33 |
| CHEMBL4102459 | — | — | 1 | 8.20 |
| CHEMBL4076436 | — | — | 1 | 8.17 |
| CHEMBL4078185 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075127 | — | Ki | = | 1.03 | nM | 8.99 |
| CHEMBL118271 | — | Ki | = | 1.58 | nM | 8.80 |
| CHEMBL4104877 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL4094707 | — | Ki | = | 2.06 | nM | 8.69 |
| CHEMBL4064556 | — | Ki | = | 2.84 | nM | 8.55 |
| CHEMBL4086079 | — | Ki | = | 4.68 | nM | 8.33 |
| CHEMBL4102459 | — | Ki | = | 6.26 | nM | 8.20 |
| CHEMBL4076436 | — | Ki | = | 6.75 | nM | 8.17 |
| CHEMBL4078185 | — | Ki | = | 78.0 | nM | 7.11 |