Assay Detail
Binding
CHEMBL4015779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to N-terminal His6-tagged human BCL6 BTB domain C8Q/C67R/C84N mutant expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance spectrometry
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 6.94 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4066850 | — | — | 1 | 8.47 |
| CHEMBL4090962 | — | — | 1 | 8.30 |
| CHEMBL4094351 | — | — | 1 | 8.19 |
| CHEMBL4093431 | — | — | 1 | 7.66 |
| CHEMBL4072699 | — | — | 1 | 6.41 |
| CHEMBL4077836 | — | — | 1 | 6.30 |
| CHEMBL4061857 | — | — | 1 | 5.96 |
| CHEMBL4084572 | — | — | 1 | 4.22 |
| CHEMBL4071527 | — | — | 1 | - |
| CHEMBL4092313 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4066850 | — | Kd | = | 3.4 | nM | 8.47 |
| CHEMBL4090962 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL4094351 | — | Kd | = | 6.5 | nM | 8.19 |
| CHEMBL4093431 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL4072699 | — | Kd | = | 390.0 | nM | 6.41 |
| CHEMBL4077836 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL4061857 | — | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL4084572 | — | Kd | = | 60000.0 | nM | 4.22 |
| CHEMBL4071527 | — | Kd | = | 689000.0 | nM | - |
| CHEMBL4092313 | — | Kd | = | 319000.0 | nM | - |