Assay Detail
Binding
CHEMBL4015787
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Inhibition of GAL4 DNA binding domain fused BCL6 BTB domain (unknown origin) expressed in HEK 293T/17 cells after 24 hrs by Bright-Glo luciferase cell reporter assay
31
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.99 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100303 | — | — | 2 | 7.10 |
| CHEMBL4092565 | — | — | 2 | 7.00 |
| CHEMBL4073463 | — | — | 2 | 6.90 |
| CHEMBL4064865 | — | — | 2 | 6.70 |
| CHEMBL4062105 | — | — | 2 | 6.40 |
| CHEMBL4096773 | — | — | 2 | 6.32 |
| CHEMBL4083842 | — | — | 2 | 6.10 |
| CHEMBL4084806 | — | — | 2 | 5.96 |
| CHEMBL4094351 | — | — | 1 | 5.70 |
| CHEMBL4102754 | — | — | 2 | 5.50 |
| CHEMBL4101172 | — | — | 1 | 5.40 |
| CHEMBL4090962 | — | — | 2 | 5.40 |
| CHEMBL4078747 | — | — | 2 | 5.30 |
| CHEMBL4063061 | — | — | 2 | 5.21 |
| CHEMBL4093418 | — | — | 1 | 5.20 |
| CHEMBL4083173 | — | — | 1 | 5.00 |
| CHEMBL4085689 | — | — | 1 | 4.80 |
| CHEMBL4061302 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100303 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL4100303 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4092565 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4092565 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4073463 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL4073463 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4064865 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4064865 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4062105 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL4062105 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4096773 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4096773 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL4083842 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL4083842 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4084806 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4084806 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL4094351 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL4102754 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL4102754 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4090962 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4101172 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL4090962 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4078747 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL4078747 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4063061 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4063061 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4093418 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL4083173 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4085689 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL4061302 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4061302 | — | IC50 | > | 31622.78 | nM | - |