Assay Detail
Binding
CHEMBL4015804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta in human PBMC assessed as reduction in anti-human CD28 antibody stimulated IL-6 secretion levels after 72 hrs by ELISA
7
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.86 | 8.90 |
| pIC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069027 | — | — | 2 | 8.90 |
| CHEMBL1213082 | — | — | 2 | 7.60 |
| CHEMBL4090825 | — | — | 1 | 7.30 |
| CHEMBL4080605 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069027 | — | IC50 | = | 1.259 | nM | 8.90 |
| CHEMBL4069027 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL1213082 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1213082 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4090825 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL4080605 | — | pIC50 | - | — | - | |
| CHEMBL4080605 | — | pIC50 | - | — | - |