Assay Detail
Binding
CHEMBL4015807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human D2SR expressed in CHO cell membranes by radioligand binding assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for β-Arrestin-Biased D2R Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.29 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2165126 | — | — | 1 | 9.70 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.42 |
| CHEMBL4072780 | — | — | 1 | 9.17 |
| CHEMBL4102628 | — | — | 1 | 9.09 |
| CHEMBL4100183 | — | — | 1 | 9.07 |
| CHEMBL4083239 | — | — | 1 | 9.00 |
| CHEMBL4064186 | — | — | 1 | 8.82 |
| CHEMBL4064742 | — | — | 1 | 8.80 |
| CHEMBL4099666 | — | — | 1 | 8.70 |
| CHEMBL4091933 | — | — | 1 | 8.66 |
| CHEMBL4092441 | — | — | 1 | 8.43 |
| CHEMBL4073330 | — | — | 1 | 7.72 |
| CHEMBL4061986 | — | — | 1 | 7.60 |
| CHEMBL4084690 | — | — | 1 | 7.43 |
| CHEMBL4091507 | — | — | 1 | 7.34 |
| CHEMBL4083727 | — | — | 1 | 7.17 |
| CHEMBL4068702 | — | — | 1 | 6.66 |
| CHEMBL4070604 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2165126 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 0.38 | nM | 9.42 |
| CHEMBL4072780 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL4102628 | — | Ki | = | 0.81 | nM | 9.09 |
| CHEMBL4100183 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL4083239 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4064186 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4064742 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4099666 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4091933 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL4092441 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4073330 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL4061986 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4084690 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL4091507 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL4083727 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL4068702 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL4070604 | — | Ki | = | 440.0 | nM | 6.36 |